Metabolism of Propionic Acid in Animal Tissues
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منابع مشابه
Metabolism of Propionic Acid in Animal Tissues
The conversion of propionyl coenzyme A to succinyl-CoA involves carboxylation to methylmalonyl-Cob (a), isomerization of methyhnalonyECoA (a) to its enantiomorph methyhnalonylCoA (b), and isomerization of the latter to succinyl-CoA (3). Since methylmalonyl-CoA (a) has recently been shown to have the D configuration (4, 5), the reversible reaction catalyzed by methylmalonyl-CoA racemase will hen...
متن کاملMetabolism of Propionic Acid in Animal Tissues. Xii. Properties of Mammalian Methylmalonyl Coenzyme a Mutase.
The conversion of propionyl coenzyme A to succinyl-CoA involves carboxylation to methylmalonyl-Cob (a), isomerization of methyhnalonyECoA (a) to its enantiomorph methyhnalonylCoA (b), and isomerization of the latter to succinyl-CoA (3). Since methylmalonyl-CoA (a) has recently been shown to have the D configuration (4, 5), the reversible reaction catalyzed by methylmalonyl-CoA racemase will hen...
متن کاملMetabolism of propionic acid in animal tissues. V. Purification and properties of propionyl carboxylase.
action 2a, might react according to Reaction 3, in the presence of propionyl-CoA carboxylase, to form methylmalonyl-CoA. In order to clarify the mechanism of propionyl-CoA carboxylation further purification of the ‘Yluorokinase” and carboxylase systems was undertaken. L’F1uorokinase” was crystallized from rabbit muscle and, as already reported (4), appears to be identical with pyruvic kinase, t...
متن کاملCCXXXIII. METABOLISM OF a-KETOGLUTARIC ACID IN ANIMAL TISSUES
DEWAN [1938] and Adler et al. [1939] reported that certain enzyme preparations obtained from heart muscle bring about a reductive amination of ac-ketoglutaric acid. The hydrogen required in this reaction may be provided from other dehydrogenase systems via coenzyme I or II, especially from the ,-hydroxybutyric and i8ocitric dehydrogenases, according to the schemes: (1) ac-ketoglutaric acid+NH3+...
متن کاملPropionic acid metabolism in mouse liver slices.
Odd carbon fatty acids are considered to be oxidized in tissue by successive fl oxidation in much the same way that even carbon members of the series are (14). The terminal S-carbon unit has been investigated to some extent. Atchley (5) demonstrated propionic acid as an end-product in the oxidation of valeric acid by a rabbit enzyme system. Studies on malonate inhibition with odd carbon fatty a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)83959-5